Gene
grin2bb
- ID
- ZDB-GENE-061207-27
- Name
- glutamate receptor, ionotropic, N-methyl D-aspartate 2B, genome duplicate b
- Symbol
- grin2bb Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable NMDA glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in excitatory postsynaptic potential; glutamatergic synaptic transmission; and long-term synaptic potentiation. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in postsynaptic membrane. Predicted to be part of NMDA selective glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; autosomal dominant intellectual developmental disorder 6; developmental and epileptic encephalopathy 27; neurodegenerative disease (multiple); and nicotine dependence. Orthologous to human GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Zoodsma et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la013686Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021225Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la021226Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9856 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa12697 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18703 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19556 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sbu311 | Allele with one deletion | Exon 11 | Unknown | CRISPR | |
| sbu312 | Allele with one deletion | Exon 11 | Unknown | CRISPR | |
| sbu313 | Allele with one deletion | Exon 11 | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-grin2bb | Zoodsma et al., 2022 | |
| CRISPR2-grin2bb | (2) | |
| CRISPR3-grin2bb | (2) | |
| CRISPR4-grin2bb | Weinschutz Mendes et al., 2023 | |
| MO1-grin2bb | N/A | Angom et al., 2024 |
| MO2-grin2bb | N/A | Angom et al., 2024 |
| MO3-grin2bb | N/A | Angom et al., 2024 |
| MO4-grin2bb | N/A | Angom et al., 2024 |
| MO5-grin2bb | N/A | Angom et al., 2024 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant intellectual developmental disorder 6 | Alliance | Intellectual developmental disorder, autosomal dominant 6, with or without seizures | 613970 |
| developmental and epileptic encephalopathy 27 | Alliance | Developmental and epileptic encephalopathy 27 | 616139 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001320 | Ionotropic glutamate receptor, C-terminal |
| Domain | IPR001828 | Receptor, ligand binding region |
| Domain | IPR018884 | Glutamate [NMDA] receptor, epsilon subunit, C-terminal |
| Domain | IPR019594 | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain |
| Family | IPR001508 | Ionotropic glutamate receptor, metazoa |
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Domain Details Per Protein
| Protein | Length | Glutamate [NMDA] receptor, epsilon subunit, C-terminal | Ionotropic glutamate receptor | Ionotropic glutamate receptor, C-terminal | Ionotropic glutamate receptor, L-glutamate and glycine-binding domain | Ionotropic glutamate receptor, metazoa | Periplasmic binding protein-like I | Receptor, ligand binding region |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1NH89
|
1770 | |||||||
|
UniProtKB:A0A8M6YZH9
|
1488 | |||||||
|
UniProtKB:A0A8M6Z5Y2
|
1218 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
grin2bb-201
(1)
|
Ensembl | 9,345 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-132L20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-243A20 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-48A12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128337 (1) | 5313 nt | ||
| Genomic | GenBank:BX901927 (1) | 152042 nt | ||
| Polypeptide | UniProtKB:A0A8M1NH89 (1) | 1770 aa |
- Zebrafish Nomenclature Committee (2025) Nomenclature Data Curation (2025). Nomenclature Committee Submission.
- Angom, R.S., Joshi, A., Patowary, A., Sivadas, A., Ramasamy, S., K V, S., Kaushik, K., Sabharwal, A., Lalwani, M.K., K, S., Singh, N., Scaria, V., Sivasubbu, S. (2024) Forward genetic screen using a gene-breaking trap approach identifies a novel role of grin2bb-associated RNA transcript (grin2bbART) in zebrafish heart function. Frontiers in cell and developmental biology. 12:13392921339292
- Guo, J., Zou, Z., Dou, X., Zhao, X., Wang, Y., Wei, L., Pi, Y., Wang, Y., He, C., Guo, S. (2024) Zebrafish Mbd5 binds to RNA m5C and regulates histone deubiquitylation and gene expression in development metabolism and behavior. Nucleic acids research. 52(8):4257-4275
- Weinschutz Mendes, H., Neelakantan, U., Liu, Y., Fitzpatrick, S.E., Chen, T., Wu, W., Pruitt, A., Jin, D.S., Jamadagni, P., Carlson, M., Lacadie, C.M., Enriquez, K.D., Li, N., Zhao, D., Ijaz, S., Sakai, C., Szi, C., Rooney, B., Ghosh, M., Nwabudike, I., Gorodezky, A., Chowdhury, S., Zaheer, M., McLaughlin, S., Fernandez, J.M., Wu, J., Eilbott, J.A., Vander Wyk, B., Rihel, J., Papademetris, X., Wang, Z., Hoffman, E.J. (2023) High-throughput functional analysis of autism genes in zebrafish identifies convergence in dopaminergic and neuroimmune pathways. Cell Reports. 42:112243112243
- Geng, Y., Zhang, T., Alonzo, I.G., Godar, S.C., Yates, C., Pluimer, B.R., Harrison, D.L., Nath, A.K., Yeh, J.J., Drummond, I.A., Bortolato, M., Peterson, R.T. (2022) Top2a promotes the development of social behavior via PRC2 and H3K27me3. Science advances. 8:eabm7069
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Zoodsma, J.D., Keegan, E.J., Moody, G.R., Bhandiwad, A.A., Napoli, A.J., Burgess, H.A., Wollmuth, L.P., Sirotkin, H.I. (2022) Disruption of grin2B, an ASD-associated gene, produces social deficits in zebrafish. Molecular autism. 13:38
- Gawel, K., Kukula-Koch, W., Banono, N.S., Nieoczym, D., Targowska-Duda, K.M., Czernicka, L., Parada-Turska, J., Esguerra, C.V. (2021) 6-Gingerol, a Major Constituent of Zingiber officinale Rhizoma, Exerts Anticonvulsant Activity in the Pentylenetetrazole-Induced Seizure Model in Larval Zebrafish. International Journal of Molecular Sciences. 22(14):
- Liu, C., Wang, Y., Deng, J., Lin, J., Hu, C., Li, Q., Xu, X. (2021) Social Deficits and Repetitive Behaviors Are Improved by Early Postnatal Low-Dose VPA Intervention in a Novel shank3-Deficient Zebrafish Model. Frontiers in neuroscience. 15:682054
- Tsata, V., Kroehne, V., Reinhardt, S., El-Armouche, A., Brand, M., Wagner, M., Reimer, M.M. (2019) Electrophysiological Properties of Adult Zebrafish Oligodendrocyte Progenitor Cells. Frontiers in Cellular Neuroscience. 13:102
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