Gene
tpcn2
- ID
- ZDB-GENE-061103-202
- Name
- two pore segment channel 2
- Symbol
- tpcn2 Nomenclature History
- Previous Names
-
- fi42c05
- im:7140344
- wu:fi42c05
- zgc:152898
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable monoatomic cation channel activity. Acts upstream of or within calcium-mediated signaling; regulation of myotome development; and skeletal myofibril assembly. Predicted to be located in lysosome. Predicted to be active in lysosomal membrane. Is expressed in slow muscle cell. Human ortholog(s) of this gene implicated in pigmentation disease. Orthologous to human TPCN2 (two pore segment channel 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7140344 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| [Skin/hair/eye pigmentation 10, blond/brown hair] | 612267 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ion transport domain | Two pore channel protein 2 | Voltage-dependent channel domain superfamily |
|---|---|---|---|---|
|
UniProtKB:A0JMD4
|
774 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available