Gene

spire1a

ID

ZDB-GENE-061013-119

Name

spire-type actin nucleation factor 1a

Symbol

spire1a Nomenclature History

Previous Names

si:ch211-215i13.1
si:zc215i13.1
zgc:153436

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to have actin binding activity. Predicted to be involved in formin-nucleated actin cable assembly and positive regulation of double-strand break repair. Predicted to localize to several cellular components, including cleavage furrow; cytoplasmic vesicle membrane; and perinuclear region of cytoplasm. Orthologous to human SPIRE1 (spire type actin nucleation factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With spire1a Human Ortholog

No data available

Associated With spire1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011019	KIND domain
Domain	IPR029905	Protein Spire homolog 1, FYVE-related domain
Family	IPR029901	Protein Spire
Homologous_superfamily	IPR011011	Zinc finger, FYVE/PHD-type
Homologous_superfamily	IPR013083	Zinc finger, RING/FYVE/PHD-type

Domain Details Per Protein

Protein	Length	KIND domain	Protein Spire	Protein Spire homolog 1, FYVE-related domain	Zinc finger, FYVE/PHD-type	Zinc finger, RING/FYVE/PHD-type
UniProtKB:A0A8M3AL19 InterPro	736
UniProtKB:A0A8M3AKA9 InterPro	772
UniProtKB:A0A0R4ITV6 InterPro	775
UniProtKB:A0A8M3B3M7 InterPro	766
UniProtKB:Q1LYM3 InterPro	761
UniProtKB:A0A8M2B6B0 InterPro	767
UniProtKB:A0A0R4IHM3 InterPro	781
UniProtKB:A0A8M2B6P4 InterPro	751