ZFIN is now using GRCz12tu for Genomic Data
Gene
foxp1a
- ID
- ZDB-GENE-060929-624
- Name
- forkhead box P1a
- Symbol
- foxp1a Nomenclature History
- Previous Names
-
- im:7146611
- wu:fb97f01
- zgc:154010
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in animal gross anatomical part developmental process and negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in brain; dorsal telencephalon; and ventral wall of dorsal aorta. Human ortholog(s) of this gene implicated in several diseases, including Barrett's esophagus; carcinoma (multiple); congenital heart disease; intellectual disability-severe speech delay-mild dysmorphism syndrome; and peritonitis. Orthologous to human FOXP1 (forkhead box P1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| intellectual disability-severe speech delay-mild dysmorphism syndrome | Alliance | Intellectual developmental disorder with language impairment with or without autistic features | 613670 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR032354 | FOXP, coiled-coil domain |
| Domain | IPR047412 | Forkhead box protein P1/P2, forkhead domain |
| Family | IPR050998 | Forkhead box protein P |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Forkhead box protein P | Forkhead box protein P1/P2, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXP, coiled-coil domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1Q4T2 | InterPro | 637 | |||||||
| UniProtKB:A0A2R8Q1R5 | InterPro | 638 | |||||||
| UniProtKB:A0A8N7XJ37 | InterPro | 433 | |||||||
| UniProtKB:A0A8M9P554 | InterPro | 605 | |||||||
| UniProtKB:A0A8M9PF34 | InterPro | 604 | |||||||
| UniProtKB:A0A8M2B938 | InterPro | 553 | |||||||
| UniProtKB:A0ACD6B7V4 | InterPro | 638 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
foxp1a-201
(1)
|
Ensembl | 1,449 nt | ||
| mRNA |
foxp1a-202
(1)
|
Ensembl | 3,042 nt | ||
| mRNA |
foxp1a-204
(1)
|
Ensembl | 558 nt | ||
| mRNA |
foxp1a-205
(1)
|
Ensembl | 1,305 nt | ||
| mRNA |
foxp1a-206
(1)
|
Ensembl | 6,526 nt | ||
| ncRNA |
foxp1a-003
(1)
|
Ensembl | 470 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers