gck

ID

ZDB-GENE-060825-204

Name

glucokinase (hexokinase 4)

Symbol

gck Nomenclature History

Previous Names

DrGLK (1)
fb57f10
hex4 (1)
wu:fb57f10 (1)
zgc:153643

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable fructokinase activity; glucokinase activity; and mannokinase activity. Acts upstream of or within glucose homeostasis; pancreas regeneration; and type B pancreatic cell development. Predicted to be located in mitochondrion and nucleus. Predicted to be active in cytoplasmic side of mitochondrial outer membrane and cytosol. Is expressed in several structures, including digestive system; female organism; heart; male organism; and muscle. Human ortholog(s) of this gene implicated in artery disease (multiple) and glucose metabolism disease (multiple). Orthologous to human GCK (glucokinase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

40 figures from 30 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 2 figures from O'Hare et al., 2016
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gck Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
familial hyperinsulinemic hypoglycemia 3	Alliance	Hyperinsulinemic hypoglycemia, familial, 3	602485
maturity-onset diabetes of the young type 2	Alliance	MODY, type II	125851
permanent neonatal diabetes mellitus	Alliance	Diabetes mellitus, permanent neonatal 1	606176
type 2 diabetes mellitus	Alliance	Diabetes mellitus, noninsulin-dependent, late onset	125853

Associated With gck Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR019807	Hexokinase, binding site
Domain	IPR022672	Hexokinase, N-terminal
Domain	IPR022673	Hexokinase, C-terminal
Family	IPR001312	Hexokinase
Homologous_superfamily	IPR043129	ATPase, nucleotide binding domain

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:F1RC38	InterPro	476
UniProtKB:A0AC58G875	InterPro	476
UniProtKB:A0AC58G880	InterPro	261
UniProtKB:A0AC58G881	InterPro	476
UniProtKB:A0AC58G882	InterPro	476