Gene
tlk2
- ID
- ZDB-GENE-060623-36
- Name
- tousled-like kinase 2
- Symbol
- tlk2 Nomenclature History
- Previous Names
-
- wu:fi16h09
- wu:fi30g12
- zgc:136697
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to have protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; peptidyl-serine phosphorylation; and regulation of chromatin assembly or disassembly. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in autosomal dominant non-syndromic intellectual disability. Orthologous to human TLK2 (tousled like kinase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Intellectual developmental disorder, autosomal dominant 57 | 618050 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|
|
UniProtKB:A0A2R8QUZ6
|
697 | ||||
|
UniProtKB:A0A8M9PXE3
|
696 | ||||
|
UniProtKB:Q1ECX4
|
697 |
Interactions and Pathways
No data available
Plasmids
No data available