Gene
cacna1ba
- ID
- ZDB-GENE-060531-44
- Name
- calcium channel, voltage-dependent, N type, alpha 1B subunit, a
- Symbol
- cacna1ba Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable high voltage-gated calcium channel activity. Predicted to be involved in calcium ion import across plasma membrane and chemical synaptic transmission. Predicted to act upstream of or within calcium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of voltage-gated calcium channel complex. Predicted to be active in neuronal cell body. Is expressed in atrium; brain; cardiac ventricle; and liver. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la015633Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa1562 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20442 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20443 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26487 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31446 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33621 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33622 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa40450 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa40451 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements | 618497 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR014873 | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain |
| Domain | IPR031649 | Voltage-dependent L-type calcium channel, IQ-associated domain |
| Family | IPR002077 | Voltage-dependent calcium channel, alpha-1 subunit |
| Family | IPR005447 | Voltage-dependent calcium channel, N-type, alpha-1 subunit |
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Domain Details Per Protein
| Protein | Additional Resources | Length | Ion transport domain | Voltage-dependent calcium channel alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit | Voltage-dependent calcium channel, alpha-1 subunit, IQ domain | Voltage-dependent calcium channel, N-type, alpha-1 subunit | Voltage-dependent channel domain superfamily | Voltage-dependent L-type calcium channel, IQ-associated domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AZM5 | InterPro | 2357 | |||||||
| UniProtKB:A0A8M9Q3D8 | InterPro | 2365 | |||||||
| UniProtKB:A0A8M6Z0K7 | InterPro | 2369 | |||||||
| UniProtKB:A0A8M3ASG9 | InterPro | 2378 | |||||||
| UniProtKB:T2B1R0 | InterPro | 2194 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cacna1ba-201
(1)
|
Ensembl | 6,939 nt | ||
| mRNA |
cacna1ba-202
(1)
|
Ensembl | 6,813 nt | ||
| mRNA |
cacna1ba-203
(1)
|
Ensembl | 6,585 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-238E12 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-225K7 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001114548 (1) | 6939 nt | ||
| Genomic | GenBank:BX571772 (2) | 125812 nt | ||
| Polypeptide | UniProtKB:A0A8M3ASG9 (1) | 2378 aa |
- Haverinen, J., Hassinen, M., Dash, S.N., Vornanen, M. (2018) Expression of calcium channel transcripts in the zebrafish heart: dominance of T-type channels. The Journal of experimental biology. 221(Pt 10)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Moravec, C.E., Samuel, J., Weng, W., Wood, I.C., Sirotkin, H.I. (2016) Maternal Rest/Nrsf Regulates Zebrafish Behavior through snap25a/b. The Journal of neuroscience : the official journal of the Society for Neuroscience. 36:9407-19
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wen, H., Linhoff, M.W., Hubbard, J.M., Nelson, N.R., Stensland, D., Dallman, J., Mandel, G., and Brehm, P. (2013) Zebrafish calls for reinterpretation for the roles of p/q calcium channels in neuromuscular transmission. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(17):7384-7392
- Sanhueza, D., Montoya, A., Sierralta, J., and Kukuljan, M. (2009) Expression of voltage-activated calcium channels in the early zebrafish embryo. Zygote (Cambridge, England). 17(2):131-135
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
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