Gene
spns2
- ID
- ZDB-GENE-030131-5843
- Name
- SPNS lysolipid transporter 2, sphingosine-1-phosphate
- Symbol
- spns2 Nomenclature History
- Previous Names
-
- fi20h04
- si:dkey-7b17.4
- toh
- wu:fi20h04
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Involved in several processes, including branching involved in blood vessel morphogenesis; embryonic organ development; and sphingosine-1-phosphate receptor signaling pathway. Predicted to localize to endosome membrane; integral component of membrane; and plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 115. Is expressed in several structures, including blastodisc; cardiovascular system; intermediate cell mass of mesoderm; tail bud; and yolk. Orthologous to human SPNS2 (sphingolipid transporter 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 18 figures from 6 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive nonsyndromic deafness 115 | Alliance | ?Deafness, autosomal recessive 115 | 618457 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Major facilitator superfamily | Major facilitator superfamily domain | MFS transporter superfamily | Protein spinster-like |
|---|---|---|---|---|---|
|
UniProtKB:A2SWM2
|
504 | ||||
|
UniProtKB:A9JRX4
|
105 |
Interactions and Pathways
No data available
Plasmids
No data available