Gene
arvcfb
- ID
- ZDB-GENE-060526-60
- Name
- ARVCF delta catenin family member b
- Symbol
- arvcfb Nomenclature History
- Previous Names
-
- si:ch211-173n20.1 (1)
- wu:fc11a08
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable cadherin binding activity. Predicted to be involved in cell-cell adhesion. Predicted to act upstream of or within cell adhesion. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Human ortholog(s) of this gene implicated in DiGeorge syndrome. Orthologous to human ARVCF (ARVCF delta catenin family member).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Hsu et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la024927Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la024928Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa13911 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33605 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33606 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Armadillo | Armadillo-like helical | Armadillo-type fold | Plakophilin/Delta catenin |
|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASI4 | InterPro | 1009 | ||||
| UniProtKB:A0A8M3ASI2 | InterPro | 1048 | ||||
| UniProtKB:A0A8M9PXY3 | InterPro | 966 | ||||
| UniProtKB:A0A8M9QE79 | InterPro | 998 | ||||
| UniProtKB:A2BGY1 | InterPro | 986 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arvcfb-201
(1)
|
Ensembl | 2,961 nt | ||
| mRNA |
arvcfb-202
(1)
|
Ensembl | 575 nt | ||
| mRNA |
arvcfb-203
(1)
|
Ensembl | 679 nt | ||
| mRNA |
arvcfb-204
(1)
|
Ensembl | 9,165 nt | ||
| mRNA |
arvcfb-206
(1)
|
Ensembl | 774 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-173N20 | ZFIN Curated Data | |
| Contained in | BAC | CH211-214J8 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-97G11 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-104K17 | ZFIN Curated Data | |
| Encodes | EST | fc11a08 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128534 (1) | 2961 nt | ||
| Genomic | GenBank:CR382292 (1) | 178208 nt | ||
| Polypeptide | UniProtKB:A0A8M3ASI2 (1) | 1048 aa |
- Campbell, P.D., Lee, I., Thyme, S., Granato, M. (2023) Mitochondrial proteins encoded by the 22q11.2 neurodevelopmental locus regulate neural stem and progenitor cell proliferation. Molecular psychiatry. 28(9):3769-3781
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Guna, A., Butcher, N.J., Bassett, A.S. (2015) Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms. Journal of neurodevelopmental disorders. 7:18
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Hsu, C.L., Muerdter, C.P., Knickerbocker, A.D., Walsh, R.M., Zepeda-Rivera, M.A., Depner, K.H., Sangesland, M., Cisneros, T.B., Kim, J.Y., Sanchez-Vazquez, P., Cherezova, L., Regan, R.D., Bahrami, N.M., Gray, E.A., Chan, A.Y., Chen, T., Rao, M.Y., and Hille, M.B. (2012) Cdc42 GTPase and Rac1 GTPase act downstream of p120 catenin and require GTP exchange during gastrulation of zebrafish mesoderm. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(10):1545-1561
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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