Gene
rasa4
- ID
- ZDB-GENE-060526-349
- Name
- RAS p21 protein activator 4
- Symbol
- rasa4 Nomenclature History
- Previous Names
-
- si:dkey-93f15.3
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable GTPase activator activity; metal ion binding activity; and phospholipid binding activity. Predicted to act upstream of or within cellular response to calcium ion; intracellular signal transduction; and negative regulation of Ras protein signal transduction. Orthologous to several human genes including RASA4 (RAS p21 protein activator 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Gomez et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa2226 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa5749 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa11873 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa18002 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18178 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33731 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33732 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa33733 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | C2 domain | C2 domain superfamily | PH-like domain superfamily | Pleckstrin homology domain | RASA4, PH domain | Ras GTPase-activating domain | Ras GTPase-activating protein | Ras GTPase-activating protein, conserved site | Rho GTPase activation protein | Zinc finger, Btk motif |
|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A2CE77
|
800 | ||||||||||
|
UniProtKB:A0A0R4IE78
|
806 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-191D17 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-32E10 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-93F15 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001099451 (1) | |||
| Genomic | GenBank:BX901917 (1) | 238589 nt | ||
| Polypeptide | UniProtKB:A0A0R4IE78 (1) | 806 aa |
- Park, G., Burroughs-Garcia, J., Foster, C.A., Hasan, A., Borga, C., Frazer, J.K. (2020) Zebrafish B cell acute lymphoblastic leukemia: new findings in an old model. Oncotarget. 11:1292-1305
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Gomez, G., Lee, J.H., Veldman, M.B., Lu, J., Xiao, X., and Lin, S. (2012) Identification of Vascular and Hematopoietic Genes Downstream of etsrp by Deep Sequencing in Zebrafish. PLoS One. 7(3):e31658
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