Gene

map4k6

ID

ZDB-GENE-060512-339

Name

mitogen-activated protein kinase kinase kinase kinase 6

Symbol

map4k6 Nomenclature History

Previous Names

zgc:136354 (1)

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to have MAP kinase kinase kinase kinase activity. Predicted to be involved in activation of protein kinase activity; intracellular signal transduction; and regulation of mitotic cell cycle. Predicted to localize to cytoplasm. Orthologous to human MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With map4k6 Human Ortholog

No data available

Associated With map4k6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001180	Citron homology (CNH) domain
Family	IPR021160	Mitogen-activated protein (MAP) kinase kinase kinase kinase
Family	IPR050629	STE20/SPS1-related Proline-Alanine-rich Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily