Gene
capn1b
- ID
- ZDB-GENE-060503-491
- Name
- calpain 1, (mu/I) large subunit b
- Symbol
- capn1b Nomenclature History
- Previous Names
-
- si:ch211-203k12.4
- si:dkeyp-101g1.3
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Is expressed in brain; embryonic structure; myotome; and neurons. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 76. Orthologous to several human genes including CAPN11 (calpain 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hereditary spastic paraplegia 76 | Alliance | Spastic paraplegia 76, autosomal recessive | 616907 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR000169 | Cysteine peptidase, cysteine active site |
| Binding_site | IPR018247 | EF-Hand 1, calcium-binding site |
| Domain | IPR001300 | Peptidase C2, calpain, catalytic domain |
| Domain | IPR002048 | EF-hand domain |
| Domain | IPR022682 | Peptidase C2, calpain, large subunit, domain III |
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Domain Details Per Protein
| Protein | Length | Calpain large subunit, domain III superfamily | Calpain subdomain III | Cysteine peptidase, cysteine active site | EF-Hand 1, calcium-binding site | EF-hand domain | EF-hand domain pair | Papain-like cysteine peptidase superfamily | Peptidase C2, calpain, catalytic domain | Peptidase C2, calpain, domain III | Peptidase C2, calpain family | Peptidase C2, calpain, large subunit, domain III |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2BLC4
|
704 | |||||||||||
|
UniProtKB:A5PMP1
|
700 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
capn1b-201
(1)
|
Ensembl | 2,103 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-203K12 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-101G1 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001144795 (1) | 2103 nt | ||
| Genomic | GenBank:BX004801 (1) | 113290 nt | ||
| Polypeptide | UniProtKB:A0A8M2BLC4 (1) | 704 aa |
- Han, S., Zhang, D., Dong, Q., Wang, X., Wang, L. (2021) Overexpression of neuroserpin in larval and adult zebrafish shows different behavioral phenotypes. Neuroscience letters. 762:136175
- Han, S., Fei, F., Sun, S., Zhang, D., Dong, Q., Wang, X., Wang, L. (2020) Increased anxiety was found in serpini1 knockout zebrafish larval. Biochemical and Biophysical Research Communications. 534:1013-1019
- Ma, Z., Zhu, P., Shi, H., Guo, L., Zhang, Q., Chen, Y., Chen, S., Zhang, Z., Peng, J., Chen, J. (2019) PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Nature. 568(7751):259-263
- Coomer, C.E., Morris, A.C. (2018) Capn5 Expression in the Healthy and Regenerating Zebrafish Retina. Investigative ophthalmology & visual science. 59:3643-3654
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Bugel, S.M., Wehmas, L.C., La Du, J.K., Tanguay, R.L. (2016) Phenotype anchoring in zebrafish reveals a potential role for matrix metalloproteinases (MMPs) in tamoxifen's effects on skin epithelium. Toxicology and applied pharmacology. 296:31-41
- Gan-Or, Z., Bouslam, N., Birouk, N., Lissouba, A., Chambers, D.B., Vérièpe, J., Androschuck, A., Laurent, S.B., Rochefort, D., Spiegelman, D., Dionne-Laporte, A., Szuto, A., Liao, M., Figlewicz, D.A., Bouhouche, A., Benomar, A., Yahyaoui, M., Ouazzani, R., Yoon, G., Dupré, N., Suchowersky, O., Bolduc, F.V., Parker, J.A., Dion, P.A., Drapeau, P., Rouleau, G.A., Bencheikh, B.O. (2016) Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. American journal of human genetics. 98:1038-1046
- Tao, T., Shi, H., Guan, Y., Huang, D., Chen, Y., Lane, D.P., Chen, J., and Peng, J. (2013) Def defines a conserved nucleolar pathway that leads p53 to proteasome-independent degradation. Cell Research. 23(5):620-634
- Lepage, S.E., and Bruce, A.E. (2008) Characterization and comparative expression of zebrafish calpain system genes during early development. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(3):819-829
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