Gene

nhsl3

ID

ZDB-GENE-060503-393

Name

NHS like 3

Symbol

nhsl3 Nomenclature History

Previous Names

si:ch211-194e15.5 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Description

Predicted to be involved in cell differentiation. Orthologous to human NHSL3 (NHS like 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa1502	Allele with one point mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
sa11053	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this)
sa13145	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa15406	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With nhsl3 Human Ortholog

No data available

Associated With nhsl3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR024845	Actin remodeling regulator NHS-like

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Domain Details Per Protein

Protein	Length	Actin remodeling regulator NHS-like
UniProtKB:A0A8M3B3L1 InterPro	1340
UniProtKB:Q1LWM5 InterPro	1325
UniProtKB:A0A8M2B664 InterPro	1394
UniProtKB:A0A8M3AK96 InterPro	1400

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Transcripts

Genome Browsers

Genome Build: GRCz11Chromosome: 19

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	si:ch211-194e15.5-201 (1) Ensembl	Ensembl		3,978 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-194E15	BX547927	ZFIN Curated Data

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_001083090 (1)	3978 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	RefSeq:NW_018395051 (1)		Select Tool MegaBLAST
Polypeptide	UniProtKB:A0A8M3AK96 (1)	1400 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	NHSL3	1	Ensembl:ENSG00000162522 Gene:57648 HGNC:29301	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Nhsl3	4	Ensembl:ENSMUSG00000050390 MGI:2140651 Gene:97130	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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