Gene

avil

ID

ZDB-GENE-060421-6683

Name

advillin

Symbol

avil Nomenclature History

Previous Names

zgc:136857

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable actin filament binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within actin filament capping and cytoskeleton organization. Predicted to be active in actin cytoskeleton and cytoplasm. Human ortholog(s) of this gene implicated in nephrotic syndrome type 21. Orthologous to human AVIL (advillin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With avil Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
nephrotic syndrome type 21	Alliance	Nephrotic syndrome, type 21	618594

Associated With avil Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003128	Villin headpiece
Domain	IPR007123	Gelsolin-like domain
Family	IPR007122	Villin/Gelsolin
Homologous_superfamily	IPR029006	ADF-H/Gelsolin-like domain superfamily
Homologous_superfamily	IPR036180	Gelsolin-like domain superfamily
Homologous_superfamily	IPR036886	Villin headpiece domain superfamily

Domain Details Per Protein

Protein	Length	ADF-H/Gelsolin-like domain superfamily	Gelsolin-like domain	Gelsolin-like domain superfamily	Villin/Gelsolin	Villin headpiece	Villin headpiece domain superfamily
UniProtKB:Q1RLT7 InterPro	811

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	avil-201 (1) Ensembl	Ensembl		2,645 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations