Gene
ccn1l2
- ID
- ZDB-GENE-060404-5
- Name
- cellular communication network factor 1, like 2
- Symbol
- ccn1l2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable heparin binding activity and integrin binding activity. Predicted to be involved in several processes, including cell adhesion; positive regulation of cell differentiation; and positive regulation of cell migration. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix and extracellular space. Is expressed in prechordal plate.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Park et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-ccn1l2 | N/A | Park et al., 2019 |
| MO2-ccn1l2 | N/A | Park et al., 2019 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | CCN, TSP1 domain | Cellular Communication Network Factor | Cystine knot, C-terminal | Glycoprotein hormone subunit beta | Growth factor receptor cysteine-rich domain superfamily | Insulin-like growth factor-binding protein, IGFBP | Thrombospondin type-1 (TSP1) repeat | Thrombospondin type-1 (TSP1) repeat superfamily | VWFC domain |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A0R4IXA2 | InterPro | 373 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cyr61l2-201
(1)
|
Ensembl | 4,195 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-112O19 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:158158 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001080987 (1) | 4230 nt | ||
| Genomic | GenBank:CR847897 (1) | 164571 nt | ||
| Polypeptide | UniProtKB:A0A0R4IXA2 (1) | 373 aa |
No data available
- Zhu, M., Li, Y., Shen, Q., Gong, Z., Liu, D. (2024) Sex disparity in zebrafish liver cell proliferation after partial hepatectomy is regulated by sex hormone receptors and the S100A1-YAP signaling cascade. Disease models & mechanisms. 17(10):
- Li, H., Luo, Q., Cai, S., Tie, R., Meng, Y., Shan, W., Xu, Y., Zeng, X., Qian, P., Huang, H. (2023) Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells. Stem Cell Research & Therapy. 14:117117
- Park, M.H., Kim, A.K., Manandhar, S., Oh, S.Y., Jang, G.H., Kang, L., Lee, D.W., Hyeon, D.Y., Lee, S.H., Lee, H.E., Huh, T.L., Suh, S.H., Hwang, D., Byun, K., Park, H.C., Lee, Y.M. (2019) CCN1 interlinks integrin and Hippo pathway to autoregulate tip cell activity. eLIFE. 8:
- Cox, A.G., Tsomides, A., Yimlamai, D., Hwang, K.L., Miesfeld, J., Galli, G.G., Fowl, B.H., Fort, M., Ma, K.Y., Sullivan, M.R., Hosios, A.M., Snay, E., Yuan, M., Brown, K.K., Lien, E.C., Chhangawala, S., Steinhauser, M.L., Asara, J.M., Houvras, Y., Link, B., Vander Heiden, M.G., Camargo, F.D., Goessling, W. (2018) Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth. The EMBO journal. 37(22):
- Cox, A.G., Hwang, K.L., Brown, K.K., Evason, K.J., Beltz, S., Tsomides, A., O'Connor, K., Galli, G.G., Yimlamai, D., Chhangawala, S., Yuan, M., Lien, E.C., Wucherpfennig, J., Nissim, S., Minami, A., Cohen, D.E., Camargo, F.D., Asara, J.M., Houvras, Y., Stainier, D.Y., Goessling, W. (2016) Yap reprograms glutamine metabolism to increase nucleotide biosynthesis and enable liver growth. Nature cell biology. 18(8):886-96
- Muth-Köhne, E., Westphal-Settele, K., Brückner, J., Konradi, S., Schiller, V., Schäfers, C., Teigeler, M., Fenske, M. (2016) Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test. Aquatic toxicology (Amsterdam, Netherlands). 176:116-127
- Rossier, N.M., Chew, G., Zhang, K., Riva, F., Fent, K. (2016) Activity of binary mixtures of drospirenone with progesterone and 17α-ethinylestradiol in vitro and in vivo. Aquatic toxicology (Amsterdam, Netherlands). 174:109-122
- Schiller, V., Wichmann, A., Kriehuber, R., Schäfers, C., Fischer, R., and Fenske, M. (2013) Transcriptome alterations in zebrafish embryos after exposure to environmental estrogens and anti-androgens can reveal endocrine disruption. Reproductive toxicology (Elmsford, N.Y.). 42:210-23
- Fernando, C.A., Conrad, P.A., Bartels, C.F., Marques, T., To, M., Balow, S.A., Nakamura, Y., and Warman, M.L. (2010) Temporal and spatial expression of CCN genes in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(6):1755-1767
- Kuo, M.W., Postlethwait, J., Lee, W.C., Lou, S.W., Chan, W.K., and Chung, B.C. (2005) Gene duplication, gene loss and evolution of expression domains in the vertebrate nuclear receptor NR5A (Ftz-F1) family. The Biochemical journal. 389(Pt 1):19-26
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