Gene
cubn
- ID
- ZDB-GENE-060228-6
- Name
- cubilin (intrinsic factor-cobalamin receptor)
- Symbol
- cubn Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 24 Mapping Details/Browsers
- Description
- Predicted to enable serine-type endopeptidase activity. Predicted to be involved in animal organ development. Predicted to be active in extracellular space. Is expressed in pleuroperitoneal region. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human CUBN (cubilin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 4 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Park et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| megaloblastic anemia | Alliance | Imerslund-Grasbeck syndrome 1 | 261100 |
| [Proteinuria, chronic benign] | 618884 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR013032 | EGF-like, conserved site |
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000859 | CUB domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR024731 | EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Homologous_superfamily | IPR035914 | Spermadhesin, CUB domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | CUB domain | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like, conserved site | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | NOTCH1 EGF-like calcium-binding domain | Spermadhesin, CUB domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PME6 | InterPro | 3626 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available