Gene

tanc2a

ID

ZDB-GENE-060130-180

Name

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2a

Symbol

tanc2a Nomenclature History

Previous Names

tanc2
sb:eu814

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Description

Predicted to be involved in regulation of dendritic spine morphogenesis. Predicted to be located in synapse. Predicted to be active in dendritic spine. Is expressed in hindbrain; neural rod; olfactory placode; pectoral fin; and retina. Human ortholog(s) of this gene implicated in intellectual developmental disorder with autistic features and language delay, with or without seizures. Orthologous to human TANC2 (tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from Thisse et al., 2005

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu814 (16 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tanc2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
intellectual developmental disorder with autistic features and language delay, with or without seizures	Alliance	Intellectual developmental disorder with autistic features and language delay, with or without seizures	618906

Associated With tanc2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR050889	Dendritic Spine Regulation and Scaffold
Homologous_superfamily	IPR011990	Tetratricopeptide-like helical domain superfamily
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat
Repeat	IPR019734	Tetratricopeptide repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	Dendritic Spine Regulation and Scaffold	P-loop containing nucleoside triphosphate hydrolase	Tetratricopeptide-like helical domain superfamily	Tetratricopeptide repeat
UniProtKB:F1RE33 InterPro	1985
UniProtKB:A0A2R8Q7B6 InterPro	1995
UniProtKB:A0A8M9Q3C4 InterPro	1335
UniProtKB:A0A8M9PDJ7 InterPro	1949
UniProtKB:A0A8M9Q7F7 InterPro	1893

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tanc2a-201 (1) Ensembl	Ensembl	8,053 nt	Select Tool ZFIN BLAST
mRNA	tanc2a-204 (1) Ensembl	Ensembl	10,480 nt	Select Tool ZFIN BLAST
mRNA	tanc2a-205 (1) Ensembl	Ensembl	10,567 nt	Select Tool ZFIN BLAST
mRNA	tanc2a-206 (1) Ensembl	Ensembl	6,804 nt	Select Tool ZFIN BLAST
ncRNA	tanc2a-002 (1) Ensembl	Ensembl	520 nt	Select Tool ZFIN BLAST
ncRNA	tanc2a-003 (1) Ensembl	Ensembl	807 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations