ZFIN is now using GRCz12tu for Genomic Data
Gene
drd4-rs
- ID
- ZDB-GENE-051113-172
- Name
- dopamine receptor D4 related sequence
- Symbol
- drd4-rs Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gi/Go. Predicted to be involved in adenylate cyclase-inhibiting dopamine receptor signaling pathway and negative regulation of glutamatergic synaptic transmission. Predicted to be located in membrane and synapse. Predicted to be active in plasma membrane. Is expressed in adenohypophyseal placode; central nervous system; otic vesicle; and pharyngeal arch 3-7 skeleton. Human ortholog(s) of this gene implicated in disease of mental health (multiple); liver cirrhosis; and movement disease. Orthologous to human DRD4 (dopamine receptor D4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 8 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Dopamine D4 receptor | Dopamine receptor family | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|---|
| UniProtKB:Q32PM9 | InterPro | 418 | ||||
| UniProtKB:A0A8M1N4D2 | InterPro | 418 | ||||
| UniProtKB:A0AC58J6H4 | InterPro | 330 | ||||
| UniProtKB:A0AC58J6H7 | InterPro | 418 | ||||
| UniProtKB:A0AC58J6I3 | InterPro | 418 | ||||
| UniProtKB:A0AC58J6I5 | InterPro | 418 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
drd4-rs-201
(1)
|
Ensembl | 1,716 nt | ||
| mRNA |
drd4-rs-202
(1)
|
Ensembl | 6,292 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers