Gene
magi2a
- ID
- ZDB-GENE-050810-4
- Name
- membrane associated guanylate kinase, WW and PDZ domain containing 2a
- Symbol
- magi2a Nomenclature History
- Previous Names
-
- magi2
- fb82g11
- si:dkey-97c7.1 (1)
- si:dkeyp-86a5.1
- wu:fb82g11
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have SMAD binding activity; receptor signaling complex adaptor activity; and signaling receptor binding activity. Involved in pronephric glomerulus development. Predicted to localize to cell-cell junction; cytoplasm; and dendrite. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Is expressed in pronephric glomerulus. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Dong et al., 2015
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 15 | Alliance | Nephrotic syndrome, type 15 | 617609 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001202 | WW domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR041489 | PDZ domain 6 |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036020 | WW domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
Domain Details Per Protein
| Protein | Length | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | PDZ domain | PDZ domain 6 | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | WW domain | WW domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M6Z5C9
|
1494 | |||||||||
|
UniProtKB:A0A8M6YY15
|
1283 | |||||||||
|
UniProtKB:A0A8M6Z5D1
|
1311 | |||||||||
|
UniProtKB:A0A8M6YZJ4
|
1428 | |||||||||
|
UniProtKB:A0A8M6Z5Z3
|
1427 | |||||||||
|
UniProtKB:A0A8M6YY10
|
1495 | |||||||||
|
UniProtKB:A0A8M9PHB4
|
1493 | |||||||||
|
UniProtKB:A0A8M6YX18
|
1494 | |||||||||
|
UniProtKB:F1Q897
|
1503 | |||||||||
|
UniProtKB:A0A8M6YX22
|
1312 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
magi2a-202
(1)
|
Havana | 3825 nt |
Interactions and Pathways
No data available
Plasmids
No data available