Gene

vps16

ID

ZDB-GENE-050809-9

Name

VPS16 core subunit of CORVET and HOPS complexes

Symbol

vps16 Nomenclature History

Previous Names

im:6907749
wu:fc34a07
wu:fl62a06
zgc:162584

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to have actin binding activity. Predicted to be involved in endosomal transport; regulation of SNARE complex assembly; and regulation of vacuole fusion, non-autophagic. Predicted to localize to HOPS complex and endosome. Orthologous to human VPS16 (VPS16 core subunit of CORVET and HOPS complexes).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:6907749 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 6 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vps16 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dystonia 30	Alliance	Dystonia 30	619291

Associated With vps16 Via Experimental Models

Human Disease	Fish	Conditions	Citations
lysosomal storage disease	AB + CRISPR1-vps16	standard conditions	Sofou et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006925	Vps16, C-terminal
Domain	IPR006926	Vps16, N-terminal
Family	IPR016534	Vacuolar protein sorting-associated protein 16
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily
Homologous_superfamily	IPR038132	Vps16, C-terminal domain superfamily