Gene
fynb
- ID
- ZDB-GENE-050706-89
- Name
- FYN proto-oncogene, Src family tyrosine kinase b
- Symbol
- fynb Nomenclature History
- Previous Names
-
- fyn-like (1)
- im:6908851
- si:dkey-119m7.5
- zgc:109996
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to have non-membrane spanning protein tyrosine kinase activity and signaling receptor binding activity. Involved in convergent extension involved in gastrulation; fin regeneration; and regulation of protein kinase activity. Predicted to localize to extrinsic component of cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and schizophrenia. Is expressed in caudal fin. Orthologous to human FYN (FYN proto-oncogene, Src family tyrosine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Yoo et al., 2012
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR035750 | Fyn/Yrk, SH3 domain |
| Domain | IPR047924 | Fyn/Yrk, SH2 domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Fyn/Yrk, SH2 domain | Fyn/Yrk, SH3 domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P2R3
|
544 | ||||||||||||
|
UniProtKB:F1RDG9
|
544 | ||||||||||||
|
UniProtKB:A0A8M3AKJ9
|
489 |
Interactions and Pathways
No data available
Plasmids
No data available