Gene
lims2
- ID
- ZDB-GENE-050522-56
- Name
- LIM and senescent cell antigen-like domains 2
- Symbol
- lims2 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable metal ion binding activity. Acts upstream of or within heart contraction and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be active in cell-cell junction; cytoplasm; and focal adhesion. Is expressed in adaxial cell; myotome; pectoral fin musculature; and somite. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2W. Orthologous to several human genes including LIMS3 (LIM zinc finger domain containing 3) and LIMS4 (LIM zinc finger domain containing 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112257 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Meder et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive limb-girdle muscular dystrophy type 2W | Alliance | ?Muscular dystrophy, autosomal recessive, with cardiomyopathy and triangular tongue | 616827 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | LIM and senescent cell antigen-like-containing domain protein 1/2-like | LIM and senescent cell antigen-like-containing domain protein 1-4-like | LIMS1/2-like, LIM domain 1 | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|
| UniProtKB:Q502G3 | InterPro | 377 | ||||
| UniProtKB:A0A8M9PS33 | InterPro | 378 | ||||
| UniProtKB:A0A8M1N667 | InterPro | 377 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available