ZFIN is now using GRCz12tu for Genomic Data

Gene

ints8

ID

ZDB-GENE-050522-556

Name

integrator complex subunit 8

Symbol

ints8 Nomenclature History

Previous Names

zgc:111823 (1)

Type

protein_coding_gene

Location

Chr: 19 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to be involved in snRNA 3'-end processing. Predicted to be located in chromosome and nucleus. Predicted to be part of integrator complex. Human ortholog(s) of this gene implicated in cerebellar hypoplasia. Orthologous to human INTS8 (integrator complex subunit 8).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:111823 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ints8 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		?Neurodevelopmental disorder with cerebellar hypoplasia and spasticity	618572

Associated With ints8 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR057980	Integrator complex subunit 8, TPR repeats
Family	IPR038751	INTS8

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A3KQN9	InterPro	996
UniProtKB:A0A8M3B3G1	InterPro	607
UniProtKB:A0AB32T5R4	InterPro	887
UniProtKB:A0AC58HY54	InterPro	664
UniProtKB:A0AC58HY58	InterPro	630
UniProtKB:A0AC58HY60	InterPro	630
UniProtKB:A0AC58HY63	InterPro	539

Transcripts

Genome Browsers

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ints8-201 (1) Ensembl	Ensembl	3,262 nt	Select Tool ZFIN BLAST
mRNA	ints8-202 (1) Ensembl	Ensembl	3,272 nt	Select Tool ZFIN BLAST
mRNA	ints8-203 (1) Ensembl	Ensembl	470 nt	Select Tool ZFIN BLAST
mRNA	ints8-205 (1) Ensembl	Ensembl	829 nt	Select Tool ZFIN BLAST
mRNA	ints8-206 (1) Ensembl	Ensembl	761 nt	Select Tool ZFIN BLAST
mRNA	ints8-207 (1) Ensembl	Ensembl	7,039 nt	Select Tool ZFIN BLAST
ncRNA	ints8-002 (1) Ensembl	Ensembl	667 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

ZFIN

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations