ZFIN is now using GRCz12tu for Genomic Data
Gene
ptbp1a
- ID
- ZDB-GENE-050522-492
- Name
- polypyrimidine tract binding protein 1a
- Symbol
- ptbp1a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable mRNA binding activity. Acts upstream of or within several processes, including intestinal epithelial structure maintenance; negative regulation of Notch signaling pathway; and positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in STAD syndrome. Orthologous to human PTBP1 (polypyrimidine tract binding protein 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 11 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| STAD syndrome | Alliance | STAD syndrome | 621495 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000504 | RNA recognition motif domain |
| Domain | IPR021790 | PTBP1-like, RNA recognition motif 2 |
| Domain | IPR035000 | PTBP1, RNA recognition motif 1 |
| Domain | IPR035001 | PTBP1, RNA recognition motif 3 |
| Domain | IPR055204 | Heterogeneous nuclear ribonucleoprotein L, RRM domain |
| Family | IPR006536 | HnRNP-L/PTB |
| Homologous_superfamily | IPR012677 | Nucleotide-binding alpha-beta plait domain superfamily |
| Homologous_superfamily | IPR035979 | RNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Heterogeneous nuclear ribonucleoprotein L, RRM domain | HnRNP-L/PTB | Nucleotide-binding alpha-beta plait domain superfamily | PTBP1-like, RNA recognition motif 2 | PTBP1, RNA recognition motif 1 | PTBP1, RNA recognition motif 3 | RNA-binding domain superfamily | RNA recognition motif domain |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q503D3 | InterPro | 574 | ||||||||
| UniProtKB:A0A8M9QFQ9 | InterPro | 573 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ptbp1a-201
(1)
|
Ensembl | 3,855 nt | ||
| ncRNA |
ptbp1a-002
(1)
|
Ensembl | 541 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers