Gene

tdg.1

ID

ZDB-GENE-050522-44

Name

thymine DNA glycosylase, tandem duplicate 1

Symbol

tdg.1 Nomenclature History

Previous Names

tdg
wu:fb44b11
zgc:110622

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to have pyrimidine-specific mismatch base pair DNA N-glycosylase activity and uracil DNA N-glycosylase activity. Predicted to be involved in base-excision repair, AP site formation. Predicted to localize to nucleus. Is expressed in retina. Orthologous to human TDG (thymine DNA glycosylase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:110622 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from Manesia et al., 2017
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tdg.1 Human Ortholog

No data available

Associated With tdg.1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR005122	Uracil-DNA glycosylase-like
Family	IPR003310	G/T mismatch-specific thymine DNA glycosylasee TDG-like, eukaryotes
Family	IPR015637	Uracil DNA glycosylase family 2
Homologous_superfamily	IPR036895	Uracil-DNA glycosylase-like domain superfamily