Gene
tubb2
- ID
- ZDB-GENE-050522-384
- Name
- tubulin, beta 2A class IIa
- Symbol
- tubb2 Nomenclature History
- Previous Names
-
- tubb2a
- zgc:112335
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Predicted to have GTP binding activity. Predicted to be involved in microtubule cytoskeleton organization and mitotic cell cycle. Predicted to localize to cytoplasm and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 5. Orthologous to human TUBB2A (tubulin beta 2A class IIa).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:112335 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
complex cortical dysplasia with other brain malformations 5 | Alliance | Cortical dysplasia, complex, with other brain malformations 5 | 615763 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Binding_site | IPR013838 | Beta tubulin, autoregulation binding site |
Conserved_site | IPR017975 | Tubulin, conserved site |
Domain | IPR003008 | Tubulin/FtsZ, GTPase domain |
Domain | IPR018316 | Tubulin/FtsZ, 2-layer sandwich domain |
Family | IPR000217 | Tubulin |
Family | IPR002453 | Beta tubulin |
Homologous_superfamily | IPR008280 | Tubulin/FtsZ, C-terminal |
Homologous_superfamily | IPR023123 | Tubulin, C-terminal |
Homologous_superfamily | IPR036525 | Tubulin/FtsZ, GTPase domain superfamily |
Homologous_superfamily | IPR037103 | Tubulin/FtsZ-like, C-terminal domain |
Domain Details Per Protein
Protein | Length | Beta tubulin | Beta tubulin, autoregulation binding site | Tubulin | Tubulin, conserved site | Tubulin, C-terminal | Tubulin/FtsZ, 2-layer sandwich domain | Tubulin/FtsZ, C-terminal | Tubulin/FtsZ, GTPase domain | Tubulin/FtsZ, GTPase domain superfamily | Tubulin/FtsZ-like, C-terminal domain |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:Q4VBI6
|
449 |
Interactions and Pathways
No data available
Plasmids
No data available