ZFIN is now using GRCz12tu for Genomic Data

Gene

rragca

ID

ZDB-GENE-050522-355

Name

Ras-related GTP binding Ca

Symbol

rragca Nomenclature History

Previous Names

rragc
zgc:111971 (1)

Type

protein_coding_gene

Location

Chr: 16 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable GTP binding activity and GTPase activity. Predicted to be involved in cellular response to starvation; negative regulation of autophagy; and positive regulation of TORC1 signaling. Predicted to be located in cytosol; lysosomal membrane; and nucleoplasm. Predicted to be part of Gtr1-Gtr2 GTPase complex. Predicted to be active in lysosome and nucleus. Is expressed in heart. Used to study cardiomyopathy. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human RRAGC (Ras related GTP binding C).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:111971 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from Kim et al., 2021
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rragca Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Long-Olsen-Distelmaier syndrome	620609

Associated With rragca Via Experimental Models

Human Disease	Fish	Conditions	Citations
cardiomyopathy	rragca^xu087/xu087 (WIK)	standard conditions	Kim et al., 2021

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR006762	Gtr1/RagA G protein
Family	IPR039400	RagC/D
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase

Domain Details Per Protein

Protein	Additional Resources	Length	Gtr1/RagA G protein	P-loop containing nucleoside triphosphate hydrolase	RagC/D
UniProtKB:Q502N9	InterPro	380

Transcripts

Genome Browsers

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	rragca-201 (1) Ensembl	Ensembl		2,324 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Genome Browsers

NCBI Map Viewer

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations