Gene

abcg5

ID

ZDB-GENE-050517-40

Name

ATP-binding cassette, sub-family G (WHITE), member 5

Symbol

abcg5 Nomenclature History

Previous Names

sterolin 1

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable ATPase-coupled transmembrane transporter activity. Predicted to be involved in cholesterol efflux; cholesterol homeostasis; and transmembrane transport. Predicted to be located in membrane. Predicted to be part of ATP-binding activity cassette (ABC) transporter complex. Predicted to be active in apical plasma membrane. Human ortholog(s) of this gene implicated in arteriosclerosis; sitosterolemia 1; and sitosterolemia 2. Orthologous to human ABCG5 (ATP binding cassette subfamily G member 5).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With abcg5 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
sitosterolemia 2	Alliance	Sitosterolemia 2	618666

Associated With abcg5 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017871	ABC transporter-like, conserved site
Domain	IPR003439	ABC transporter-like, ATP-binding domain
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR013525	ABC-2 type transporter, transmembrane domain
Domain	IPR043926	ABC transporter family G domain
Family	IPR050352	ATP-binding cassette subfamily G transporters
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase