Gene
abcd1
- ID
- ZDB-GENE-050517-27
- Name
- ATP-binding cassette, sub-family D (ALD), member 1
- Symbol
- abcd1 Nomenclature History
- Previous Names
-
- zgc:172102 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to have several functions, including ATP binding activity; ATPase activity; and long-chain fatty acid transporter activity. Involved in several processes, including oligodendrocyte development; positive regulation of myelination; and swimming behavior. Predicted to localize to integral component of membrane and peroxisomal membrane. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Is expressed in central nervous system; floor plate; gut; interrenal gland; and pronephros. Orthologous to several human genes including ABCD1 (ATP binding cassette subfamily D member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Strachan et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| adrenoleukodystrophy | Alliance | Adrenoleukodystrophy | 300100 |
| adrenoleukodystrophy | Alliance | Adrenomyeloneuropathy, adult | 300100 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| adrenoleukodystrophy | abcd1zc92/zc92 | standard conditions | Raas et al., 2021 |
| adrenoleukodystrophy | abcd1sa509/sa509 | standard conditions | (2) |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036640 | ABC transporter type 1, transmembrane domain superfamily |
Domain Details Per Protein
| Protein | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
|
UniProtKB:F1RBC8
|
766 | ||||||
|
UniProtKB:A9JRC4
|
640 |
Interactions and Pathways
No data available
Plasmids
No data available