Gene
abcb11a
- ID
- ZDB-GENE-050517-13
- Name
- ATP-binding cassette, sub-family B (MDR/TAP), member 11a
- Symbol
- abcb11a Nomenclature History
- Previous Names
-
- fc21d02
- wu:fc21d02
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to enable ABC-type bile acid transporter activity and canalicular bile acid transmembrane transporter activity. Predicted to be involved in canalicular bile acid transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in apical plasma membrane. Is expressed in intestine. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 2; intrahepatic cholestasis; liver cirrhosis; and progressive familial intrahepatic cholestasis 2. Orthologous to human ABCB11 (ATP binding cassette subfamily B member 11).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Ellis et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa18599 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa18968 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa21601 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34768 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44714 | Allele with one point mutation | Unknown | Unknown | ENU | |
| sa45380 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| benign recurrent intrahepatic cholestasis 2 | Alliance | Cholestasis, benign recurrent intrahepatic, 2 | 605479 |
| progressive familial intrahepatic cholestasis 2 | Alliance | Cholestasis, progressive familial intrahepatic 2 | 601847 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR017871 | ABC transporter-like, conserved site |
| Domain | IPR003439 | ABC transporter-like, ATP-binding domain |
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR011527 | ABC transporter type 1, transmembrane domain |
| Family | IPR039421 | Type 1 protein exporter |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | ABC transporter-like, ATP-binding domain | ABC transporter-like, conserved site | ABC transporter type 1, transmembrane domain | ABC transporter type 1, transmembrane domain superfamily | P-loop containing nucleoside triphosphate hydrolase | Type 1 protein exporter |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:F1QSX6 | InterPro | 1320 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
abcb11a-201
(1)
|
Ensembl | 3,963 nt | ||
| mRNA |
abcb11a-202
(1)
|
Ensembl | 4,922 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-278B7 | ||
| Encodes | EST | fc21d02 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068223679 (1) | 4491 nt | ||
| Genomic | GenBank:CR626882 (1) | 162232 nt | ||
| Polypeptide | UniProtKB:F1QSX6 (1) | 1320 aa |
- Wijerathna, H.M.S.M., Shanaka, K.A.S.N., Raguvaran, S.S., Jayamali, B.P.M.V., Kim, S.H., Kim, M.J., Jung, S., Lee, J. (2024) CRISPR/Cas9-Mediated fech Knockout Zebrafish: Unraveling the Pathogenesis of Erythropoietic Protoporphyria and Facilitating Drug Screening. International Journal of Molecular Sciences. 25(19):
- Chen, L., Lam, J.C., Tang, L., Hu, C., Liu, M., Lam, P.K.S., Zhou, B. (2020) Probiotic modulation of lipid metabolism disorders caused by perfluorobutanesulfonate pollution in zebrafish. Environmental science & technology. 54(12):7494-7503
- Ellis, J.L., Bove, K.E., Schuetz, E.G., Leino, D., Valencia, C.A., Schuetz, J.D., Miethke, A., Yin, C. (2017) Zebrafish abcb11b mutant reveals novel strategies to restore bile excretion impaired by bile salt export pump deficiency. Hepatology (Baltimore, Md.). 67(4):1531-1545
- Foulkes, M.J., Henry, K.M., Rougeot, J., Hooper-Greenhill, E., Loynes, C.A., Jeffrey, P., Fleming, A., Savage, C.O., Meijer, A.H., Jones, S., Renshaw, S.A. (2017) Expression and regulation of drug transporters in vertebrate neutrophils. Scientific Reports. 7:4967
- Ortiz-Villanueva, E., Navarro-Martín, L., Jaumot, J., Benavente, F., Sanz-Nebot, V., Piña, B., Tauler, R. (2017) Metabolic disruption of zebrafish (Danio rerio) embryos by bisphenol A. An integrated metabolomic and transcriptomic approach. Environmental pollution (Barking, Essex : 1987). 231:22-36
- Gebauer, J.M., Kobbe, B., Paulsson, M., Wagener, R. (2016) Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 49:106-19
- Xu, T., Zhao, J., Xu, Z., Pan, R., Yin, D. (2016) The developmental effects of pentachlorophenol on zebrafish embryos during segmentation: A systematic view. Scientific Reports. 6:25929
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Ren, J., Chung-Davidson, Y.W., Yeh, C.Y., Scott, C., Brown, T., Li, W. (2015) Genome-wide analysis of the ATP-binding cassette (ABC) transporter gene family in sea lamprey and Japanese lamprey. BMC Genomics. 16:436
- Fischer, S., Klüver, N., Burkhardt-Medicke, K., Pietsch, M., Schmidt, A.M., Wellner, P., Schirmer, K., and Luckenbach, T. (2013) Abcb4 acts as multixenobiotic transporter and active barrier against chemical uptake in zebrafish (Danio rerio) embryos. BMC Biology. 11(1):69
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