Gene

rasgrp4

ID

ZDB-GENE-050419-110

Name

RAS guanyl releasing protein 4

Symbol

rasgrp4 Nomenclature History

Previous Names

si:dkey-12o15.1

Type

protein_coding_gene

Location

Chr: 18 Mapping Details/Browsers

Description

Predicted to have calcium ion binding activity and guanyl-nucleotide exchange factor activity. Involved in lymph vessel development. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Is expressed in caudal vein plexus; dorsal aorta; head; notochord; and posterior cardinal vein. Orthologous to several human genes including RASGRP4 (RAS guanyl releasing protein 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Huang et al., 2013

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from Huang et al., 2013
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rasgrp4 Human Ortholog

No data available

Associated With rasgrp4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Binding_site	IPR018247	EF-Hand 1, calcium-binding site
Domain	IPR000651	Ras-like guanine nucleotide exchange factor, N-terminal
Domain	IPR001895	Ras guanine-nucleotide exchange factors catalytic domain
Domain	IPR002048	EF-hand domain
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR020454	Diacylglycerol/phorbol-ester binding
Family	IPR008937	Ras-like guanine nucleotide exchange factor
Homologous_superfamily	IPR011992	EF-hand domain pair
Homologous_superfamily	IPR023578	Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily	IPR036964	Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	C1-like domain superfamily	Diacylglycerol/phorbol-ester binding	EF-Hand 1, calcium-binding site	EF-hand domain	EF-hand domain pair	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Ras guanine-nucleotide exchange factor, catalytic domain superfamily	Ras guanine nucleotide exchange factor domain superfamily	Ras guanine-nucleotide exchange factors catalytic domain	Ras-like guanine nucleotide exchange factor	Ras-like guanine nucleotide exchange factor, N-terminal
UniProtKB:Q1L9A0 InterPro	687
UniProtKB:A0A8M2BKX7 InterPro	693
UniProtKB:A0A8M9PM49 InterPro	692
UniProtKB:A0A8M2BKX1 InterPro	720
UniProtKB:A0A8M2BLA4 InterPro	725
UniProtKB:A0A8M3AJR7 InterPro	724
UniProtKB:A0A8M2BKY0 InterPro	695