Gene

ppp3cb

ID

ZDB-GENE-050417-406

Name

protein phosphatase 3, catalytic subunit, beta isozyme

Symbol

ppp3cb Nomenclature History

Previous Names

wu:fq19c08
zgc:110141

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade. Predicted to localize to calcineurin complex and cytosol. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Is expressed in hatching gland; integument; nervous system; and pharyngeal arch. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

21 figures from 3 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:110141 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ppp3cb Human Ortholog

No data available

Associated With ppp3cb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type
Domain	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Domain	IPR041751	PP2B, metallophosphatase domain
Family	IPR043360	PP2B
Homologous_superfamily	IPR029052	Metallo-dependent phosphatase-like

Domain Details Per Protein

Protein	Length	Calcineurin-like phosphoesterase domain, ApaH type	Metallo-dependent phosphatase-like	PP2B	PP2B, metallophosphatase domain	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
UniProtKB:A0A8M9QGE2 InterPro	510
UniProtKB:Q568R4 InterPro	511
UniProtKB:A0A8M3AZJ8 InterPro	506
UniProtKB:A0A8M3BEY4 InterPro	522

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	ppp3cb-201 (1) Ensembl	Havana	3158 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	ppp3cb-202 (1) Ensembl	Havana	992 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations