Gene

mecr

ID
ZDB-GENE-050417-399
Name
mitochondrial trans-2-enoyl-CoA reductase
Symbol
mecr Nomenclature History
Previous Names
  • zgc:110153 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to have trans-2-enoyl-CoA reductase (NADPH) activity. Predicted to be involved in fatty acid metabolic process. Predicted to localize to mitochondrion. Human ortholog(s) of this gene implicated in dystonia. Orthologous to human MECR (mitochondrial trans-2-enoyl-CoA reductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mecr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
childhood-onset dystonia with optic atrophy and basal ganglia abnormalities Alliance Dystonia, childhood-onset, with optic atrophy and basal ganglia abnormalities 617282
Optic atrophy 16 620629
Associated With mecr Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR013149 Alcohol dehydrogenase-like, C-terminal
Domain IPR013154 Alcohol dehydrogenase-like, N-terminal
Domain IPR020843 Polyketide synthase, enoylreductase domain
Homologous_superfamily IPR011032 GroES-like superfamily
Homologous_superfamily IPR036291 NAD(P)-binding domain superfamily
Domain Details Per Protein
Protein Length Alcohol dehydrogenase-like, C-terminal Alcohol dehydrogenase-like, N-terminal GroES-like superfamily NAD(P)-binding domain superfamily Polyketide synthase, enoylreductase domain
UniProtKB:A0A8M9P7W8 190
UniProtKB:Q6GQN8 377
UniProtKB:Q568Q9 377
UniProtKB:A0A8M9NZ96 263
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations