ZFIN is now using GRCz12tu for Genomic Data
Gene
man2b1
- ID
- ZDB-GENE-050327-52
- Name
- mannosidase, alpha, class 2B, member 1
- Symbol
- man2b1 Nomenclature History
- Previous Names
-
- zgc:110815
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable alpha-mannosidase activity. Predicted to be involved in mannose metabolic process. Predicted to be located in lysosomal lumen. Predicted to be active in lysosome. Human ortholog(s) of this gene implicated in alpha-mannosidosis. Orthologous to human MAN2B1 (mannosidase alpha class 2B member 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| alpha-mannosidosis | Alliance | Mannosidosis, alpha-, types I and II | 248500 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000602 | Glycoside hydrolase family 38, N-terminal domain |
| Domain | IPR011682 | Glycosyl hydrolase family 38, C-terminal |
| Domain | IPR015341 | Glycoside hydrolase family 38, central domain |
| Domain | IPR041147 | Glycosyl hydrolases family 38, C-terminal domain |
| Domain | IPR048534 | Lysosomal alpha-mannosidase-like, central domain |
| Family | IPR050843 | Glycosyl Hydrolase Family 38 |
| Homologous_superfamily | IPR011013 | Galactose mutarotase-like domain superfamily |
| Homologous_superfamily | IPR011330 | Glycoside hydrolase/deacetylase, beta/alpha-barrel |
| Homologous_superfamily | IPR013780 | Glycosyl hydrolase, all-beta |
| Homologous_superfamily | IPR027291 | Glycoside hydrolase 38, N-terminal domain superfamily |
| Homologous_superfamily | IPR028995 | Glycoside hydrolase families 57/38, central domain superfamily |
| Homologous_superfamily | IPR037094 | Glycoside hydrolase family 38, central domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Galactose mutarotase-like domain superfamily | Glycoside hydrolase 38, N-terminal domain superfamily | Glycoside hydrolase/deacetylase, beta/alpha-barrel | Glycoside hydrolase families 57/38, central domain superfamily | Glycoside hydrolase family 38, central domain | Glycoside hydrolase family 38, central domain superfamily | Glycoside hydrolase family 38, N-terminal domain | Glycosyl hydrolase, all-beta | Glycosyl Hydrolase Family 38 | Glycosyl hydrolase family 38, C-terminal | Glycosyl hydrolases family 38, C-terminal domain | Lysosomal alpha-mannosidase-like, central domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:Q58EM3 | InterPro | 982 | ||||||||||||
| UniProtKB:A0A8M2BH83 | InterPro | 984 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
man2b1-201
(1)
|
Ensembl | 3,346 nt | ||
| mRNA |
man2b1-202
(1)
|
Ensembl | 898 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers