Gene

hsf4

ID
ZDB-GENE-050306-18
Name
heat shock transcription factor 4
Symbol
hsf4 Nomenclature History
Previous Names
  • zgc:113344
Type
protein_coding_gene
Location
Chr: 18 Mapping Details/Browsers
Description
Exhibits sequence-specific DNA binding activity. Involved in lens development in camera-type eye; positive regulation of deoxyribonuclease activity; and regulation of lens fiber cell differentiation. Predicted to localize to nucleus. Used to study cataract. Human ortholog(s) of this gene implicated in cataract and cataract 5 multiple types. Is expressed in eye; lens; and solid lens vesicle. Orthologous to human HSF4 (heat shock transcription factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
6 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
14 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hsf4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cataract 5 multiple types Alliance Cataract 5, multiple types 116800
Associated With hsf4 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000232 Heat shock factor (HSF)-type, DNA-binding
Domain IPR010542 Vertebrate heat shock transcription factor, C-terminal domain
Family IPR027725 Heat shock transcription factor family
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Heat shock factor (HSF)-type, DNA-binding Heat shock transcription factor family Vertebrate heat shock transcription factor, C-terminal domain Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:Q5CZP2 441
UniProtKB:A0A8M3AJJ3 424
UniProtKB:A0A8M9PQ64 441
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations