Gene
dlg3
- ID
- ZDB-GENE-050208-93
- Name
- discs, large homolog 3 (Drosophila)
- Symbol
- dlg3 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to be involved in several processes, including establishment or maintenance of epithelial cell apical/basal polarity; receptor clustering; and receptor localization to synapse. Predicted to colocalize with ionotropic glutamate receptor complex. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Is expressed in central nervous system; immature eye; notochord; sensory system; and ventral mesoderm. Orthologous to human DLG3 (discs large MAGUK scaffold protein 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7138640 (10 images)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 90 | Alliance | Intellectual developmental disorder, X-linked 90 | 300850 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR020590 | Guanylate kinase, conserved site |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001478 | PDZ domain |
| Domain | IPR004172 | L27 domain |
| Domain | IPR008144 | Guanylate kinase-like domain |
| Domain | IPR008145 | Guanylate kinase/L-type calcium channel beta subunit |
| Domain | IPR015143 | L27-1 |
| Domain | IPR019583 | Disks large homolog 1-4, PDZ-associated domain |
| Domain | IPR019590 | Disks large homologue 1, N-terminal PEST domain |
| Domain | IPR035763 | Disks Large homologue 3, SH3 domain |
| Family | IPR016313 | Disks large 1-like |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036034 | PDZ superfamily |
| Homologous_superfamily | IPR036892 | L27 domain superfamily |
Domain Details Per Protein
| Protein | Length | Disks large 1-like | Disks large homolog 1-4, PDZ-associated domain | Disks large homologue 1, N-terminal PEST domain | Disks Large homologue 3, SH3 domain | Guanylate kinase, conserved site | Guanylate kinase-like domain | Guanylate kinase/L-type calcium channel beta subunit | L27-1 | L27 domain | L27 domain superfamily | PDZ domain | PDZ superfamily | P-loop containing nucleoside triphosphate hydrolase | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9PZS5
|
922 | |||||||||||||||
|
UniProtKB:A0A8M9QL03
|
940 | |||||||||||||||
|
UniProtKB:A0A8M3AS60
|
831 | |||||||||||||||
|
UniProtKB:A0A8M9PZT0
|
891 | |||||||||||||||
|
UniProtKB:A0A8M9QPI0
|
912 | |||||||||||||||
|
UniProtKB:A0A8M3B0G6
|
904 | |||||||||||||||
|
UniProtKB:A0A8M3AGS5
|
914 | |||||||||||||||
|
UniProtKB:A0A8M9QBJ7
|
934 | |||||||||||||||
|
UniProtKB:A0A8M9QGS9
|
877 | |||||||||||||||
|
UniProtKB:A0A8M9QGS1
|
932 | |||||||||||||||
|
UniProtKB:A0A8M9QPH5
|
930 | |||||||||||||||
|
UniProtKB:A5PKT0
|
366 | |||||||||||||||
|
UniProtKB:A0A8M9Q5B2
|
885 | |||||||||||||||
|
UniProtKB:A0A8M9QL07
|
922 | |||||||||||||||
|
UniProtKB:A0A8M9QBK2
|
922 | |||||||||||||||
|
UniProtKB:A0A8M9QPI1
|
849 | |||||||||||||||
|
UniProtKB:A0A8M9Q1J7
|
935 | |||||||||||||||
|
UniProtKB:A0A8M9PBS2
|
515 |
Interactions and Pathways
No data available
Plasmids
No data available