Gene

pnkd

ID
ZDB-GENE-050208-278
Name
PNKD metallo-beta-lactamase domain containing
Symbol
pnkd Nomenclature History
Previous Names
  • im:7147352
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have hydroxyacylglutathione hydrolase activity. Predicted to be involved in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in paroxysmal nonkinesigenic dyskinesia 1. Orthologous to human PNKD (PNKD metallo-beta-lactamase domain containing).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Thisse et al., 2004
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With pnkd Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
paroxysmal nonkinesigenic dyskinesia 1 Alliance Paroxysmal nonkinesigenic dyskinesia 1 118800
Associated With pnkd Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001279 Metallo-beta-lactamase
Domain IPR032282 Hydroxyacylglutathione hydrolase, C-terminal domain
Domain IPR035680 Hydroxyacylglutathione hydrolase, MBL domain
Family IPR017782 Hydroxyacylglutathione hydrolase
Homologous_superfamily IPR036866 Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
Domain Details Per Protein
Protein Length Hydroxyacylglutathione hydrolase Hydroxyacylglutathione hydrolase, C-terminal domain Hydroxyacylglutathione hydrolase, MBL domain Metallo-beta-lactamase Ribonuclease Z/Hydroxyacylglutathione hydrolase-like
UniProtKB:F6NM08 361
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations