Gene

iftap

ID

ZDB-GENE-050208-187

Name

intraflagellar transport associated protein

Symbol

iftap Nomenclature History

Previous Names

im:7145024

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable intraciliary transport particle A binding activity. Predicted to be involved in acrosome reaction and spermatogenesis. Predicted to be active in 9+0 non-motile cilium and cytosol. Orthologous to human IFTAP (intraflagellar transport associated protein).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7145024 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Allele	Type	Localization	Consequence	Mutagen	Supplier
sa15742	Allele with one point mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa45018	Allele with one point mutation	Unknown	Unknown	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

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Sequence Targeting Reagents

No data available

Human Disease

Associated With iftap Human Ortholog

No data available

Associated With iftap Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR040028	Intraflagellar transport-associated protein

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Domain Details Per Protein

Protein	Length	Intraflagellar transport-associated protein
UniProtKB:A0A8M3AZH1 InterPro	153
UniProtKB:E7F3R0 InterPro	229

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Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Genome Build: GRCz11Chromosome: 25

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	im:7145024-201 (1) Ensembl	Ensembl	1,075 nt	Select Tool ZFIN BLAST
mRNA	im:7145024-202 (1) Ensembl	Ensembl	987 nt	Select Tool ZFIN BLAST
mRNA	im:7145024-203 (1) Ensembl	Ensembl	1,344 nt	Select Tool ZFIN BLAST
mRNA	im:7145024-204 (1) Ensembl	Ensembl	752 nt	Select Tool ZFIN BLAST
ncRNA	im:7145024-003 (1) Ensembl	Ensembl	646 nt	Select Tool ZFIN BLAST

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Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

No data available

Marker Relationships

Relationship	Marker Type	Marker	Accession Numbers	Citations
Contained in	BAC	CH211-256A21	AL935203	ZFIN Curated Data
Encodes	EST	IMAGE:7145024	CK682889	Thisse et al., 2004

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Sequences

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:XM_005162985 (1)	1389 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:AL935203 (1)	163572 nt	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7F3R0 (1)	229 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Species	Symbol	Chromosome	Accession #	Evidence
Human	IFTAP	11	Ensembl:ENSG00000166352 Gene:119710 OMIM:619270 HGNC:25142	Amino acid sequence comparison (1) Conserved genome location (synteny) (1)
Mouse	Iftap	2	Ensembl:ENSMUSG00000027165 MGI:1915420 Gene:68170	Conserved genome location (synteny) (1) Amino acid sequence comparison (1)

Citations

Include unpublished citations

Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549

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