Gene

shank3b

ID

ZDB-GENE-041210-74

Name

SH3 and multiple ankyrin repeat domains 3b

Symbol

shank3b Nomenclature History

Previous Names

si:dkey-153k10.1
zs3.1 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have GKAP/Homer scaffold activity and ionotropic glutamate receptor binding activity. Predicted to be involved in several processes, including nervous system development; positive regulation of synaptic transmission; and regulation of AMPA receptor activity. Predicted to colocalize with ionotropic glutamate receptor complex and postsynaptic membrane. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Phelan-McDermid syndrome and schizophrenia 15. Is expressed in brain; forebrain; and midbrain. Orthologous to human SHANK3 (SH3 and multiple ankyrin repeat domains 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 8 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With shank3b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Phelan-McDermid syndrome	Alliance	Phelan-McDermid syndrome	606232
schizophrenia 15	Alliance	{Schizophrenia 15}	613950

Associated With shank3b Via Experimental Models

Human Disease	Fish	Conditions	Citations
autism spectrum disorder	shank3b^{fdu201/fdu201} (TU)	standard conditions	Liu et al., 2018

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001452	SH3 domain
Domain	IPR001478	PDZ domain
Domain	IPR001660	Sterile alpha motif domain
Domain	IPR041489	PDZ domain 6
Homologous_superfamily	IPR013761	Sterile alpha motif/pointed domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	PDZ domain	PDZ domain 6	PDZ superfamily	SH3 domain	SH3-like domain superfamily	Sterile alpha motif domain	Sterile alpha motif/pointed domain superfamily
UniProtKB:A0A8M6YZQ6 InterPro	1605
UniProtKB:A0A8M6Z5I4 InterPro	1636
UniProtKB:A0A8M6Z644 InterPro	1551
UniProtKB:A0A8M9PQP9 InterPro	1448
UniProtKB:A0A8M6YY75 InterPro	1633
UniProtKB:A0A8M6YX80 InterPro	1455
UniProtKB:A0A8M9Q1C6 InterPro	1626
UniProtKB:A0A8M9Q4D9 InterPro	164
UniProtKB:A0A8M3ARK3 InterPro	1643
UniProtKB:A0A8M9PY09 InterPro	1598
UniProtKB:A0A8M9P8N6 InterPro	1544
UniProtKB:A0A8M9PJP8 InterPro	1636

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	shank3b-202 (1) Ensembl	Havana	5490 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	shank3b-203 (1) Ensembl	Havana	637 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations