Gene
foxp2
- ID
- ZDB-GENE-041203-2
- Name
- forkhead box P2
- Symbol
- foxp2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in response to ethanol. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; autism spectrum disorder (multiple); communication disorder (multiple); dyslexia; and major depressive disorder. Is expressed in head; heart tube; and nervous system. Orthologous to human FOXP2 (forkhead box P2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 18 figures from 8 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| speech-language disorder-1 | Alliance | Speech-language disorder-1 | 602081 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR030456 | Fork head domain conserved site 2 |
| Domain | IPR001766 | Fork head domain |
| Domain | IPR032354 | FOXP, coiled-coil domain |
| Domain | IPR047412 | Forkhead box protein P1/P2, forkhead domain |
| Family | IPR050998 | Forkhead box protein P |
| Homologous_superfamily | IPR036388 | Winged helix-like DNA-binding domain superfamily |
| Homologous_superfamily | IPR036390 | Winged helix DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | Forkhead box protein P | Forkhead box protein P1/P2, forkhead domain | Fork head domain | Fork head domain conserved site 2 | FOXP, coiled-coil domain | Winged helix DNA-binding domain superfamily | Winged helix-like DNA-binding domain superfamily |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q4JNX5
|
697 |
Interactions and Pathways
No data available
Plasmids
No data available