Gene

gnal

ID

ZDB-GENE-041114-26

Name

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type

Symbol

gnal Nomenclature History

Previous Names

GNAL1 (1)
Galpha olf2 (1)
Golf1 (1)
zgc:103521

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to localize to heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in dystonia 25. Is expressed in brain; gill; head; and peripheral olfactory organ. Orthologous to human GNAL (G protein subunit alpha L).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 4 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gnal Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
dystonia 25	Alliance	Dystonia 25	615073

Associated With gnal Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Family	IPR000367	G-protein alpha subunit, group S
Family	IPR001019	Guanine nucleotide binding protein (G-protein), alpha subunit
Homologous_superfamily	IPR011025	G protein alpha subunit, helical insertion
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase