Gene
ptp4a2b
- ID
- ZDB-GENE-041114-111
- Name
- protein tyrosine phosphatase 4A2b
- Symbol
- ptp4a2b Nomenclature History
- Previous Names
-
- PRL-2 (1)
- ptp4a2
- fc05f09
- wu:fc05f09
- wu:fi84b06
- zgc:101724
- Type
- protein_coding_gene
- Location
- Chr: 19 Mapping Details/Browsers
- Description
- Predicted to have protein tyrosine phosphatase activity. Predicted to be involved in dephosphorylation. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including fin; gut; head; myotome; and neuromast. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-ptp4a2b | N/A | Lohani et al., 2021 |
MO2-ptp4a2b | N/A | Lohani et al., 2021 |
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Human Disease
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Domain | IPR000387 | Tyrosine-specific protein phosphatases domain |
Domain | IPR003595 | Protein-tyrosine phosphatase, catalytic |
Domain | IPR020422 | Dual specificity protein phosphatase domain |
Family | IPR050561 | Protein Tyrosine Phosphatase |
Homologous_superfamily | IPR029021 | Protein-tyrosine phosphatase-like |
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Domain Details Per Protein
Protein | Length | Dual specificity protein phosphatase domain | Protein Tyrosine Phosphatase | Protein-tyrosine phosphatase, catalytic | Protein-tyrosine phosphatase-like | Tyrosine-specific protein phosphatases domain |
---|---|---|---|---|---|---|
UniProtKB:Q6TLG9
|
168 | |||||
UniProtKB:Q5U3R3
|
174 |
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Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
ptp4a2b-201
(1)
|
Ensembl | 2,222 nt | ||
mRNA |
ptp4a2b-203
(1)
|
Ensembl | 816 nt | ||
mRNA |
ptp4a2b-204
(1)
|
Ensembl | 5,641 nt | ||
ncRNA |
ptp4a2b-003
(1)
|
Ensembl | 497 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH211-197N10 | ZFIN Curated Data | |
Encodes | EST | fc05f09 | ||
Encodes | EST | fi84b06 | ZFIN Curated Data | |
Encodes | cDNA | MGC:101724 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001024098 (1) | 2218 nt | ||
Genomic | GenBank:BX957241 (1) | 199001 nt | ||
Polypeptide | UniProtKB:Q5U3R3 (1) | 174 aa |
- Lohani, S., Funato, Y., Akieda, Y., Mizutani, K., Takai, Y., Ishitani, T., Miki, H. (2021) A novel role of PRL in regulating epithelial cell density by inducing apoptosis at confluence. Journal of Cell Science. 135(2):
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Jiang, L., Romero-Carvajal, A., Haug, J.S., Seidel, C.W., Piotrowski, T. (2014) Gene-expression analysis of hair cell regeneration in the zebrafish lateral line. Proceedings of the National Academy of Sciences of the United States of America. 111:E1383-92
- Lin, M.D., Lee, H.T., Wang, S.C., Li, H.R., Hsien, H.L., Cheng, K.W., Chang, Y.D., Huang, M.L., Yu, J.K., and Chen, Y.H. (2013) Expression of phosphatase of regenerating liver family genes during embryogenesis: an evolutionary developmental analysis among Drosophila, amphioxus, and zebrafish. BMC Developmental Biology. 13:18
- Song, H.D., Sun, X.J., Deng, M., Zhang, G.W., Zhou, Y., Wu, X.Y., Sheng, Y., Chen, Y., Ruan, Z., Jiang, C.L., Fan, H.Y., Zon, L.I., Kanki, J.P., Liu, T.X., Look, A.T., and Chen, Z. (2004) Hematopoietic gene expression profile in zebrafish kidney marrow. Proceedings of the National Academy of Sciences of the United States of America. 101(46):16240-16245
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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