Gene

adgrg6

ID

ZDB-GENE-041014-357

Name

adhesion G protein-coupled receptor G6

Symbol

adgrg6 Nomenclature History

Previous Names

bge
big ears (1)
gpr126
lau
lauscher (1)
si:ch211-202p1.3 (1)
unm st49
unm_st49

Type

protein_coding_gene

Location

Chr: 20 Mapping Details/Browsers

Description

Exhibits G protein-coupled receptor activity; collagen binding activity; and extracellular matrix binding activity. Involved in several processes, including animal organ morphogenesis; cAMP-mediated signaling; and myelination. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Is expressed in several structures, including head; otic vesicle; pericardial region; pleuroperitoneal region; and sensory system. Orthologous to human ADGRG6 (adhesion G protein-coupled receptor G6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

18 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu1654 (12 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 50 figures from 18 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adgrg6 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Lethal congenital contracture syndrome 9	616503

Associated With adgrg6 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR000203	GPS motif
Conserved_site	IPR017983	GPCR, family 2, secretin-like, conserved site
Domain	IPR000859	CUB domain
Domain	IPR017981	GPCR, family 2-like, 7TM
Family	IPR000832	GPCR, family 2, secretin-like
Family	IPR001759	Pentraxin-related
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
Homologous_superfamily	IPR035914	Spermadhesin, CUB domain superfamily
Homologous_superfamily	IPR046338	GAIN domain superfamily

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	CUB domain	GAIN domain superfamily	GPCR, family 2-like, 7TM	GPCR, family 2, secretin-like	GPCR, family 2, secretin-like, conserved site	GPS motif	Pentraxin-related	Spermadhesin, CUB domain superfamily
UniProtKB:C6KFA3 InterPro	1185

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adgrg6-202 (1) Ensembl	Havana	796 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	adgrg6-203 (1) Ensembl	Havana	516 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	adgrg6-204 (1) Ensembl	Havana	4246 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations