Gene
prodha
- ID
- ZDB-GENE-041008-73
- Name
- proline dehydrogenase (oxidase) 1a
- Symbol
- prodha Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable FAD binding activity and proline dehydrogenase activity. Predicted to be involved in L-proline catabolic process to L-glutamate. Predicted to act upstream of or within L-proline catabolic process. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder; hyperprolinemia type 1; and schizophrenia 4. Orthologous to human PRODH (proline dehydrogenase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136007 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hyperprolinemia type 1 | Alliance | Hyperprolinemia, type I | 239500 |
| schizophrenia 4 | Alliance | {Schizophrenia, susceptibility to, 4} | 600850 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | FAD-linked oxidoreductase-like | Proline dehydrogenase domain | Proline oxidase family |
|---|---|---|---|---|---|
| UniProtKB:A0A8M1RHY4 | InterPro | 617 | |||
| UniProtKB:E7FFM5 | InterPro | 629 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prodha-201
(1)
|
Ensembl | 1,890 nt | ||
| mRNA |
prodha-203
(1)
|
Ensembl | 981 nt | ||
| ncRNA |
prodha-002
(1)
|
Ensembl | 771 nt |
Interactions and Pathways
No data available
Plasmids
No data available