Gene

adam10a

ID

ZDB-GENE-040917-2

Name

ADAM metallopeptidase domain 10a

Symbol

adam10a Nomenclature History

Previous Names

adam10
wu:fc03d12

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Predicted to have metalloendopeptidase activity involved in amyloid precursor protein catabolic process. Predicted to be involved in Notch signaling pathway and PMA-inducible membrane protein ectodomain proteolysis. Predicted to localize to synaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease 18 and reticulate acropigmentation of Kitamura. Orthologous to human ADAM10 (ADAM metallopeptidase domain 10).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With adam10a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Alzheimer's disease 18	Alliance	{Alzheimer disease 18, susceptibility to}	615590
reticulate acropigmentation of Kitamura	Alliance	Reticulate acropigmentation of Kitamura	615537

Associated With adam10a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001590	Peptidase M12B, ADAM/reprolysin
Domain	IPR001762	Disintegrin domain
Domain	IPR034025	ADAM10/ADAM17 catalytic domain
Domain	IPR049038	ADAM10, cysteine-rich domain
Homologous_superfamily	IPR024079	Metallopeptidase, catalytic domain superfamily
Homologous_superfamily	IPR036436	Disintegrin domain superfamily

Domain Details Per Protein

Protein	Length	ADAM10/ADAM17 catalytic domain	ADAM10, cysteine-rich domain	Disintegrin domain	Disintegrin domain superfamily	Metallopeptidase, catalytic domain superfamily	Peptidase M12B, ADAM/reprolysin
UniProtKB:A0A0R4IVX1 InterPro	751
UniProtKB:F1RA88 InterPro	762
UniProtKB:A0A1D5NT24 InterPro	763

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	adam10a-201 (1) Ensembl	Havana	4465 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	adam10a-203 (1) Ensembl	Havana	4478 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations