ZFIN is now using GRCz12tu for Genomic Data
Gene
gtf3c3
- ID
- ZDB-GENE-040914-80
- Name
- general transcription factor IIIC, polypeptide 3
- Symbol
- gtf3c3 Nomenclature History
- Previous Names
-
- im:7136784
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable RNA polymerase III general transcription initiation factor activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be part of transcription factor TFIIIC complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human GTF3C3 (general transcription factor IIIC subunit 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Thisse et al., 2004
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136784 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Abdel-Hamid et al., 2025
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures | Alliance | Neurodevelopmental disorder with dysmorphic facies, brain anomalies, and seizures | 621201 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Tetratricopeptide-like helical domain superfamily | Tetratricopeptide repeat | Transcription factor Tfc4/TFIIIC-102/Sfc4 |
|---|---|---|---|---|---|
| UniProtKB:F1RDA7 | InterPro | 918 | |||
| UniProtKB:A0AC58J1H2 | InterPro | 518 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gtf3c3-201
(1)
|
Ensembl | 2,932 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers