Gene

msrb1b

ID

ZDB-GENE-040912-88

Name

methionine sulfoxide reductase B1b

Symbol

msrb1b Nomenclature History

Previous Names

sepx1b
zgc:92822

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Description

Predicted to enable single-stranded DNA 3'-5' DNA exonuclease activity and single-stranded DNA binding activity. Predicted to be involved in resolution of meiotic recombination intermediates. Predicted to act upstream of or within innate immune response and meiotic cell cycle. Predicted to be located in cytoplasm; cytoskeleton; and nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency and spermatogenic failure 22. Orthologous to several human genes including MEIOB (meiosis specific with OB-fold).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:92822 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With msrb1b Human Ortholog

No data available

Associated With msrb1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR002579	Peptide methionine sulphoxide reductase MrsB domain
Family	IPR052150	Methionine-R-sulfoxide reductase B1
Family	IPR052469	Meiosis-specific OB domain-containing
Homologous_superfamily	IPR011057	Mss4-like superfamily
Homologous_superfamily	IPR012340	Nucleic acid-binding, OB-fold