Gene

rassf1

ID

ZDB-GENE-040912-14

Name

Ras association domain family member 1

Symbol

rassf1 Nomenclature History

Previous Names

wu:fc17f02
zgc:112224
zgc:92505

Type

protein_coding_gene

Location

Chr: 22 Mapping Details/Browsers

Description

Predicted to have metal ion binding activity. Predicted to be involved in intracellular signal transduction and regulation of microtubule cytoskeleton organization. Human ortholog(s) of this gene implicated in breast cancer; reproductive organ cancer (multiple); transitional cell carcinoma; and urinary system cancer (multiple). Is expressed in several structures, including immature eye; intermediate cell mass of mesoderm; nervous system; pharyngeal arch; and ventral mesoderm. Orthologous to human RASSF1 (Ras association domain family member 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

12 figures from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:92505 (16 images)
IMAGE:6912198 (11 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With rassf1 Human Ortholog

No data available

Associated With rassf1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000159	Ras-associating domain
Domain	IPR001368	TNFR/NGFR cysteine-rich region
Domain	IPR002219	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
Domain	IPR011524	SARAH domain
Domain	IPR033600	Ras association domain-containing protein 1, RA domain
Family	IPR033614	Ras association domain-containing protein 1-6
Homologous_superfamily	IPR029071	Ubiquitin-like domain superfamily
Homologous_superfamily	IPR046349	C1-like domain superfamily

Domain Details Per Protein

Protein	Length	C1-like domain superfamily	Protein kinase C-like, phorbol ester/diacylglycerol-binding domain	Ras-associating domain	Ras association domain-containing protein 1-6	Ras association domain-containing protein 1, RA domain	SARAH domain	TNFR/NGFR cysteine-rich region	Ubiquitin-like domain superfamily
UniProtKB:Q66HV2 InterPro	363
UniProtKB:A0A8M2BL97 InterPro	340

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	rassf1-202 (1) Ensembl	Havana	2159 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	rassf1-203 (1) Ensembl	Havana	1432 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations