Gene
eif3ha
- ID
- ZDB-GENE-040808-19
- Name
- eukaryotic translation initiation factor 3, subunit H, a
- Symbol
- eif3ha Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to contribute to translation initiation factor activity. Involved in several processes, including lateral line development; regulation of translation; and vasculature development. Predicted to localize to several cellular components, including eukaryotic 43S preinitiation complex; eukaryotic translation initiation factor 3 complex; and polysomal ribosome. Human ortholog(s) of this gene implicated in breast cancer; prostate cancer; and prostate carcinoma. Is expressed in several structures, including gut; heart; liver; nervous system; and pleuroperitoneal region. Orthologous to human EIF3H (eukaryotic translation initiation factor 3 subunit H).
- Genome Resources
- Note
- None
- Comparative Information
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7137312 (1 image)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | eIF3h, C-terminal | Eukaryotic translation initiation factor 3 subunit H | JAB1/MPN/MOV34 metalloenzyme domain | JAMM/MPN+ metalloenzymes, peptidase M67A | MPN domain |
---|---|---|---|---|---|---|
UniProtKB:Q6AXJ2
|
335 |
1 - 1 of 1
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
eif3ha-201
(1)
|
Ensembl | 1,220 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | CH73-179G5 | ZFIN Curated Data | |
Contained in | BAC | CH211-270K20 | ZFIN Curated Data | |
Contained in | BAC | DKEY-210P14 | ZFIN Curated Data | |
Encodes | EST | fj02c04 | ||
Encodes | EST | IMAGE:7137312 | Thisse et al., 2004 | |
Encodes | cDNA | MGC:101085 | ZFIN Curated Data |
1 - 6 of 6
Show
Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:NM_001003763 (1) | 1244 nt | ||
Genomic | GenBank:CU183074 (2) | 147231 nt | ||
Polypeptide | UniProtKB:Q6AXJ2 (1) | 335 aa |
- Gebauer, J.M., Kobbe, B., Paulsson, M., Wagener, R. (2016) Structure, evolution and expression of collagen XXVIII: Lessons from the zebrafish. Matrix biology : journal of the International Society for Matrix Biology. 49:106-19
- Choudhuri, A., Maitra, U., and Evans, T. (2013) Translation initiation factor eIF3h targets specific transcripts to polysomes during embryogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110(24):9818-9823
- Choudhuri, A., Evans, T., and Maitra, U. (2010) Non-core subunit eIF3h of translation initiation factor eIF3 regulates zebrafish embryonic development. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(6):1632-1644
- Tse, W.K., Eisenhaber, B., Ho, S.H., Ng, Q., Eisenhaber, F., and Jiang, Y.J. (2009) Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. BMC Genomics. 10:637
- Lucitt, M.B., Price, T.S., Pizarro, A., Wu, W., Yocum, A.K., Seiler, C., Pack, M.A., Blair, I.A., Fitzgerald, G.A., and Grosser, T. (2008) Analysis of the zebrafish proteome during embryonic development. Molecular & cellular proteomics : MCP. 7(5):981-994
- Woods, I.G., Wilson, C., Friedlander, B., Chang, P., Reyes, D.K., Nix, R., Kelly, P.D., Chu, F., Postlethwait, J.H., and Talbot, W.S. (2005) The zebrafish gene map defines ancestral vertebrate chromosomes. Genome research. 15(9):1307-1314
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
1 - 7 of 7
Show