Gene

nck2b

ID

ZDB-GENE-040801-235

Name

NCK adaptor protein 2b

Symbol

nck2b Nomenclature History

Previous Names

fd20h08
im:7147817
si:ch211-147g19.3
wu:fd20h08
zgc:92024 (1)

Type

protein_coding_gene

Location

Chr: 6 Mapping Details/Browsers

Description

Predicted to enable receptor tyrosine kinase binding activity and signaling adaptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; positive regulation of translation in response to endoplasmic reticulum stress; and regulation of response to endoplasmic reticulum stress. Predicted to act upstream of or within regulation of translation. Predicted to be located in cytosol and endoplasmic reticulum. Predicted to be active in cytoplasm. Orthologous to human NCK2 (NCK adaptor protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7147817 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With nck2b Human Ortholog

No data available

Associated With nck2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000980	SH2 domain
Domain	IPR001452	SH3 domain
Domain	IPR035559	Nck2, SH3 domain 1
Domain	IPR035560	Nck2, SH3 domain 2
Domain	IPR035561	Nck2, SH3 domain 3
Domain	IPR035883	Nck2, SH2 domain
Family	IPR017304	Cytoplasmic protein NCK
Family	IPR051184	Tyrosine-phosphorylated adapter molecule
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036860	SH2 domain superfamily